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Over the past decade, Dr. Comunale has worked collaboratively to develop biomarkers for hepatocellular carcinoma (HCC). Hepatocellular carcinoma can be caused by chronic infection with a virus (hepatitis B and C), excessive alcohol consumption or fatty liver disease. HCC is the third leading cause of liver cancer in the world today. Early detection can increase survival rates from less than 10% to over 80%. Dr. Comunale was part of a team that examined aberrant glycosylation in diseased states that resulted in protein biomarkers that have been patented in the U.S., Europe, Australia, Japan and China, and licensed to Glycotest LLC. Dr. Comunale has recently focused her research efforts on glycomic, glycoproteomic and proteomic techniques to investigate Lyme disease.

Current Graduate Students

• Aline Coelho Guadalupe, PhD – postdoctoral researcher

Past Students

• Kristina Carroll (MS Molecular Medicine)
• Colin Page (BS Computer Science - Coop)
• Elizabeth Calio (BS Psychology)
• Christopher Dobbins (BS Game Art and Production)
• John Harvey (BS Game Art and Production)
• Ben Haslund-Gourley (MD/PhD Microbiology & Immunology)
• Jintong Hou, MS (PhD Biostatistics)
• Keziah Adjei (MS Molecular Medicine)
• Quinn Williams (BS Game Design)

Patents

Mary Ann Comunale, Timothy Block, Anand Mehta and Mengun Wang
Publication number: 20190064171

Mary Ann Comunale, Anand Mehta and Timothy Block
Patent number: 7776550

Mary Ann Comunale, Anand Mehta and Timothy Block
Patent number: 9110078

鈥淎wards Ceremony Celebrates Graduate School Class of 2024鈥�
(May 14, 2024)

The East Hampton Star (February 29, 2024)

鈥淒rexel Researchers Find Possible Predictor of COVID-19 Severity鈥�
Drexel News (February 20, 2024)

Exel - 91制片厂 Research Magazine (2023)

(May 1, 2023)

Drexel Lyme Disease Diagnostic Gets a Boost from U.S. Department of Health and Human Services
Drexel News (November 21, 2022)

(November 2022)

EdSurge (April 17, 2018)

Mütter Center for Education of the College of Physicians of Philadelphia (December 21, 2017)

Chester County Press (August 29, 2017)

Selected Research Publications

Hou J, Haslund-Gourley B, Diray-Arce J,...Comunale MA.
Front Med (Lausanne) 2025 Jul 4;12:1604388. doi: 10.3389/fmed.2025.1604388

Haslund-Gourley, B.S., Woloszczuk, K., Hou, J.,... Comunale M.A.
Nat Commun 15, 404 (2024). https://doi.org/10.1038/s41467-023-44211-0

Haslund-Gourley, B., Wigdahl, B., and Comunale, M.A.
Diagnostics, 13(6), 1016. doi:https://doi.org/10.3390/diagnostics13061016 (2023)

Haslund-Gourley, Grauzam, S., Mehta, A.S., Wigdahl, B., and Comunale, M.A.
Frontiers in Immunology, 13, 949118–949118. https://doi.org/10.3389/fimmu.2022.949118 (2022)

Ma J., Zhang X, Soloveve V, Warren T, Guo F, Wu S, Su Q, Shen H, Solon E, Comunale MA, Mehta A, Guo J, Savari S, Du Y, Block T and Chang J
Antiviral Research, 150, 112-122. doi:10.1016/j.antiviral.2017.12.008, 2018

Norton P, Comunale MA, Herrera H, Wang M, Houser J, Wimmerova M, Romano P and Mehta A
Proteomics, 16(24), 3126-3136. doi:10.1002/pmic.201600064, 2016

Meibalan E, Comunale MA, Lopez AM, Bergman LW, Mehta A, Vaidya AB and Burns JM Jr.
Eukaryot Cell, 14(4), 371-384. doi:10.1128/EC.00228-14, 2015

Comunale MA, Wang M, Anbarasan N, Betesh L, Karabudak A, Moritz E, Devarajan K, Marrero J, Block T, Mehta A
Proteomics Clin Appl, 7(9-10), 690-700. doi:10.1002/prca.201200125, 2013

Comunale MA, Rodemich-Betesh L, Hafner J, Wang M, Norton P, et al.
PLoS ONE, 5(8): e12419, 2010

Comunale MA, Wang M, Hafner J, Krakover J, Rodemich L, Kopenhaver B, Long RE, Junaidi O, Bisceglie AM, Block TM, and AS Mehta
Journal of Proteome Research, 8(2): 595-602, 2009.

Wang M, Long RE, Comunale MA, Junaidi O, Marrero J, Di Bisceglie, AM, Block, TM, and AS Mehta
Cancer Epidemiology, Biomarkers & Prevention, 18(6): 1914-1921, 2009.

White KY, Rodemich L, Nyalwidhe JO, Comunale MA, Clements MA, Lance RS, Schellhammer PF, Mehta AS, Semmes OJ, and RR Drake
Journal of Proteome Research, 8(2): 620-630, 2009.

Norton PA, Comunale MA, Krakover J, Rodemich L, Pirog N, D'Amelio A, Philip R, Mehta AS, and TM Block
Journal of Cell Biochemistry, 104(1): 136-149, 2008.

Mehta AS, Long RE, Comunale MA, Wang M, Rodemich L, Krakover J, Philip R, Marrero JA, Dwek RA, and TM Block
Journal of Virology, 82(3): 1259-1270, 2008.

Comunale MA, Krakover J, Lowman M, Long RE, Philip R, Seeholzer S, Evans AA, Hann HWL, Block TM, and AS Mehta
Journal of Proteome Research, 6(5): 308-315, 2006.

Block TM, Comunale MA, Romano PM, Lowman M, Fimmel C, Tennant BT, Evans A, London WT, Blumberg B, Dwek RA, Mattu TS, and A Mehta
Proceedings of the National Academy of Sciences USA, 102 (3): 779--84, 2005.

Marrero JA, Romano PR, Nikolaeva O, Steel L, Mehta A, Fimmel CJ, Comunale MA, D'Amelio A, Lok AS, and TM Block.
Journal of Hepatology, 43(6): 1007-1012, 2005.

Comunale MA, Mattu TS, Lowman M, Evans A, London WT, Dwek RA, Block TM, and A Mehta
Proteomics: 4(3): 826-838, 2004.

Book Chapters

Glycosylation and Hepatocellular Carcinoma.
Comunale MA and Mehta A
In M. Dunn, L. Jorde, P. Little and S. Subramaniam (Eds.), Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics (Vol. 3): Wiley, 2006

Glycoproteomic Analysis by Two Dimensional Electrophoresis
Comunale MA and Mehta A
In M.A. Tainsky (Ed.), Tumor Marker Discovery (Vol. 520, pp. 59-74): Humana Press, 2009