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Awards and Honors

• Javits Neurosciences Investigator Award
• Fogarty Fellowship
• Trustees Award for Excellence in Teaching: Graduate School
• Research Achievement Award, MCP Hahnemann University

Service to the Research Community

• NIH Study Sections
• VA Office of Regeneration Research Advisory Board
• Spinal Cord Research Foundation Advisory Board
• Editorial boards: Experimental Neurology, Journal of Comparative Neurology, Neurorehabilitation and Neural Repair, Restorative Neurology, Neuroscience
• Visiting scientist: Medical Research Council in London, National Defense Medical College in Taiwan, College de France in Paris

Dr. Murray's research focused on the basic mechanisms of neural plasticity that underlie the recovery of function after injury to the CNS. These mechanisms included collateral sprouting of intact axons in response to degeneration of converging projections, restitution of function through the use of redundant systems, and axonal growth that contributes to restoration of function.

She was particularly interested in the use of cellular transplants to encourage repair processes leading to recovery of sensorimotor and autonomic function. The transplants act by rescuing neurons that are destined to die and by permitting regeneration and sprouting of some axons into the transplant and, in some cases, into the host. The function that recovers in neonates includes locomotion that is adaptable and flexible. In adults with spinal lesions, cellular transplants also rescue axotomized neurons destined to die, but regeneration is much more modest. The functional recovery is also much poorer. Using cells genetically modified to secrete trophic factors increases neuronal survival, axonal regeneration and sprouting and functional recovery after spinal injury in adults. The motor recovery can be further enhanced by administration of agents, such as serotonin, that mimic transmitters that normally act as modulators of motor function, and by physical exercise programs.

Selected Publications

Kao T, Shumsky JS, Murray M, Moxon KA
J. Neurosci;29(23):7549-57, Jun 10, 2009.

Kao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FPT, Lee DHS, Rabacchi SA, Murray M
Exp. Neurorehabil Neural Repair. 22: 262-278, 2008.

Stackhouse SK, Murray M, Shumsky JS
J. Neurotrauma 25:1039-1047, 2008.

Hayashi Y, Jacob S, Nothias J-M, McBride S, Olexa R, Simansky K, Murray M, Shumsky JS
Exp. Neurol. Submitted. 2007.

Burns AS, Jawaid S, Zhong H, Yoshihara H, Bhagat S, Murray M, Roy RR, Tessler A, Son YJ.
J. Comp. Neurol. 500:116-133, 2007.

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Boyce VS, Tumolo MA, Fischer I, Murray M, Lemay MA
J. Neurophysiol. 98(4):1988-96, 2007.

Kao T, Shumsky JS, Jacob-Vadakot S, Himes BT, Murray M, Moxon KA
Brain Res. 1112:159-168, 2006.

Yoshihama H, Shumsky J, Neuhuber B, Otsuka T, Fischer I, Murray M
Brain Research 1119:65-75, 2006.

Nothias, J-M, Mitsui T, Shumsky JS, Fischer I, Antonacci MD, Murray M
Neurorehab Neur Rep. 19:296-312, 2005.

Mitsui T, Shumsky JS, Lepore A, Murray M, Fischer I
J. Neurosci. 25: 9624-9636, 2005.

Hayashi Y, Shumsky JS, Connors T, Otsuka T, Fischer I, Tessler A, Murray M
J. Neurotrauma. 22:1267-1281, 2005.

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Anderson DK, Beattie M, Blesch A, Bresnahan J, Bunge M, Dietrich D, Dietz V, Dobkin B, Fawcett J, Fehlings M, Fischer I, Grossman R, Guest J, Hagg T, Hall ED, Houle J, Kleitman N, McDonald J, Murray M, Privat A, Reier P, Steeves J, Steward O, Tetzlaff W, Tuszynski MH, Waxman SG, Whittemore S, Wolpaw J, Young W, Zheng B
Spinal Cord 43: 453-458, 2005.

Shumsky JS, Kao T, Amato N, Simansky K, Murray M, Moxon KA.
Exp Neurol. 191:361-365, 2005.

Schwartz ED, Chin C-L, Shumsky JS, Jawad AF, Brown BK, Wehrli S, Tessler A, Murray M, Hackney DB.
Am. J. Neuroradiol 26:7-18, 2005.

Tobias CA, Han SSW, Shumsky JS, Kim D, Tumolo M, Tessler A, Murray M
J. Neurotrauma. 22:138-157, 2005.

Murray M
Progress in Brain Research. 143:133-146, 2004.

Murray M, Fischer I, Smeraski C, Tessler A, Giszter S
J. Neurotrauma. 21:405-413, 2004.

"Regeneration and sprouting in the injured spinal cord"
Murray M, Tobias CA
Topics in Spinal Cord Injury Rehabilitation. 8:37-51, 2003.

Shumsky JS, Tobias CA, Tumolo M, Long WD, Giszter SF, Murray M
Exp. Neurol. 187:114-124, 2003.

Tobias CA, Shumsky JS, Shibata M, Tuszynski MH, Fischer I, Tessler A, Murray M
Exp. Neurol. 184:97-113, 2003.

Schwartz ED, Shumsky JS, Wehrli S, Tessler A, Murray M, Hackney DB
Experimental Neurology. 182:49-63, 2003.

Liu Y, Himes BT, Murray M, Tessler A, Fischer I
Experimental Neurol. 178:150-164, 2002.

Murray M, Kim D, Liu Y, Tobias C, Tessler A, Fischer I
Brain Res. Reviews 40:292-300, 2002.

Murray M
Progress in Brain Research, 2002.

Kim D, Schallert T, Liu Y, Browarak T, Nayeri N, Tessler A, Fischer I, Murray M
Neurorehabilitation and Neural Repair. 15:141-150, 2001.

Tobias CA, Dhoot, NO, Wheatley MA, Tessler A, Murray M and Fischer I
J. Neurotrauma. 18:287-301, 2001.

Murray M and Fischer I
The Neuroscientist. 7:28-41, 2001.

Kim D, Adipudi V, Giszter S, Shibayama M, Tessler A, Murray M, Simansky KJ
J. Neurosci. 19:6213-24, 1999.

Liu Y, Kim D, Himes BT, Chow SY, Schallert T, Murray M, Tessler A, Fischer I
J. Neurosci. 19:4370-87, 1999.

Miya D, Tessler A, Giszter, S, Mori F, Murray M
J. Neurosci. 17:4856-72, 1997.

Books:

Eds. Ingoglia N, Murray M.Axonal Regeneration in the Vertebrate CNS. Marcel Dekker. New York, 2001.

Eds. Ingoglia N, M Murray. Therapies to promote CNS repair in Axonal Regeneration in the Central Nervous System. Marcel Dekkar. NYC, 2001.

Eds. Goldberger ME, Gorio A, Murray M. Development and Plasticity of the Mammalian Spinal Cord. Liviana Press. Italy, 1985.