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• American Association for Cancer Research Early-Career Hill Day Cancer Research Advocate (2023)
• Society for the ImmunoTherapy of Cancer Sparkathon 2022 Cohort Member
• American Cancer Society Postdoctoral Fellow (2020-2022)
• Ruth L. Kirschstein National Research Service Award T23 (2018-2020)

• Postdoctoral Training 鈥� Sanford Burnham Prebys Medical Discovery Institute (2017-2022)

Dr. Hope鈥檚 research is focused on unraveling cellular and molecular mechanisms underlying T cell differentiation, which a specific interest in understanding what drives T cells towards terminal differentiation and subsequently immune checkpoint blockade-resistant exhausted T cells and how we can target T cells to promote the generation of immune checkpoint blockade-sensitive progenitor T cell populations. Her lab uses models of cancer and chronic virus infection to address mechanistic-driven basic science questions related to these interests.

Graduate students: Open positions!

Defining key regulators of CD8+ T cell exhaustion

CD8+ T cells are immune cells that are highly effective in the specific killing of infected cells or tumor cells and provide protection against infection and cancer. In patients however, CD8+ T cells repeatedly exposed to pathogens or tumor antigens progressively lose their functional killing abilities and can become 鈥渆xhausted鈥�. Immune checkpoint blockade therapies have leveraged our understanding of CD8+ T cell biology to reinvigorate anti-tumor CD8+ T cell responses and their landmark success in previously non-responsive cancer patients heralded a new era for immunotherapeutics. Yet many patients and cancers have remained resistant or become refractive to existing immune checkpoint blockade therapies, highlighting the need to identify novel targets and mechanisms to limit or reverse the development of T cell exhaustion.

To better understand the fundamental biology driving T cell exhaustion and identify new ways to enhance T cell function, our lab studies the development of T cell exhaustion in models of chronic virus infection and tumors. A major interest in our research is intrinsic-mediated T cell differentiation driven by P-selectin glycoprotein-1 (PSGL-1) signaling and immune modulation from T cell crosstalk with the inflammatory or tumor microenvironment and neighboring immune cells.

Selected Publications

Hope JL, Otero DC, Bae E-A, Stairiker CJ, Palete AB, Faso HA, Lin M, Henriquez ML, Roy S, Seo H, Lei X, Wang ES, Chow S, Tinoco R, Daniels GA, Yip K, Campos AR, Yin J, Adams PD, Rao A, Bradley LM
Cell Reports. 2023 May 42(5). doi: 10.1016/j.celrep.2023.112436. Epub 2023 Apr 26. PMID: 37115668

Hope JL, Zhao M, Stairiker CJ, Kiernan CH, Carey AJ, Mueller YM, van Meurs M, Brouwers-Haspels I, Otero DC, Bae EA, Faso HA, Maas A, de Looper H, Fortina PM, Rigoutsos I, Bradley LM, Erkeland SJ, Katsikis PD
J Immunol. 2022 Feb 1;208(3):603-617. doi: 10.4049/jimmunol.2000621. Epub 2022 Jan 12. PMID: 35022277

Hope JL, Bradley LM
Science. 2021 Jan 29;371(6528):464-465. doi: 10.1126/science.abf6446. PMID: 33510014

Hope JL, Spantidea PI, Kiernan CH, Stairiker CJ, Rijsbergen LC, van Meurs M, Brouwers-Haspels I, Mueller YM, Nelson DJ, Bradley LM, Aerts JGJV, Katsikis PD
Front Immunol. 2019;10:3074. doi: 10.3389/fimmu.2019.03074. eCollection 2019. PMID: 31998326

Hope JL, Stairiker CJ, Bae EA, Otero DC, Bradley LM
Front Immunol. 2019;10:1595. doi: 10.3389/fimmu.2019.01595. eCollection 2019. Review. PMID: 31379821

Hope JL, Stairiker CJ, Spantidea PI, Gracias DT, Carey AJ, Fike AJ, van Meurs M, Brouwers-Haspels I, Rijsbergen LC, Fraietta JA, Mueller YM, Klop RC, Stelekati E, Wherry EJ, Erkeland SJ, Katsikis PD
Front Immunol. 2017;8:1696. doi: 10.3389/fimmu.2017.01696. eCollection 2017. PMID: 29358931