91制片厂

• Early Career Mentoring Award for Basic Science Faculty, 91制片厂 (2023)
• Best Advisor/Mentor Award and Best Student Advocate Award, Biomedical Science Programs, 91制片厂 Graduate School of Biomedical Sciences and Professional Studies (2022)
• Provost Award for Early Career Outstanding Scholarly Productivity, 91制片厂 (2022)
• Mary DeWitt Pettit, MD Fellowship, WMC-MCP Trust Committee, 91制片厂 (2020)
• NIAAA Young Investigator Award, Alcoholism and Stress: A Framework for Future Treatment Strategies (2020)
• Ann Kelley Memorial Fellowship, Winter Conference on Brain Research (2017)
• Young Investigator Travel Award, Research Society on Alcoholism (2016)

• Postdoctoral Fellowship - Medical University of South Carolina

Dr. Barker’s primary research interest is in dissecting the neural circuits that contribute to the development of neuropsychiatric illnesses characterized by inflexible behavior. Her lab combines traditional and cutting-edge techniques to investigate how these circuits function in an intact system to mediate behavioral flexibility, and how deficits in control over actions may result from insults such as drug and alcohol exposure.

Visit the Barker Laboratory.

The focus of the Barker Lab is the investigation of the neurobiological bases of behavioral flexibility and cognitive control, and the mechanisms by which these processes are dysregulated in neuropsychiatric illnesses. The ability to flexibly regulate behavior is critical to adapt to an ever-changing environment. Impairments in flexible actions have been observed in a number of illnesses, including obsessive compulsive disorder, addiction, PTSD and depression. A greater understanding of the neurobiological substrates mediating flexible behaviors is expected to provide insight into potential treatable targets for these illnesses.

We use a combination of in vivo electrophysiology, pharmacology, opto- and chemogenetics to determine the contribution of distinct neural circuits to the regulation of response strategy selection. In addition to investigating how these circuits function in normal learning and memory processes, we are interested in how exposure to drugs and alcohol may act on these circuits to disrupt the ability to regulate behavior, which may promote the maintenance of addictive or maladaptive behavior. Further, we are interested in how these acquired deficits in cognitive control may interact with innate differences – such as hormonal or genetic sex, or other genetic factors – to impact cognitive control over behavior.

KYW-Newsradio (1060-AM) (April 15, 2021)

eNeuro Blog (January 2019)

鈥淎rbitration of approach-avoidance conflict by ventral hippocampus鈥�
Bryant KG & Barker JM
Frontiers in Neuroscience. 14: 615337 (2020)

鈥淏rain region-dependent alterations in polysialic acid immunoreactivity across the estrous cycle鈥�
Giacometti LL, Huang F, Hamilton B & Barker JM
Hormones and Behavior. 126: 104851 (2020)

鈥淎strocyte modulation reverses ethanol dependence-induced impairments in extinction learning in female mice鈥�
Giacometti LL, Chandran K, Figueroa L & Barker JM
Neuropharmacology. 179: 108272 (2020)

鈥淪elective deficits in contingency-driven ethanol seeking following chronic ethanol exposure in male mice鈥�
Barker JM, Bryant KG, Montiel-Ramos A, Goldwasser B & Chandler LJ
Alcoholism: Clinical and Experimental Research. 44(9): 1896-1905 (2020)

鈥淪ex differences the glutamate system: implications for addiction鈥�
Giacometti LL & Barker JM
Neuroscience and Biobehavioral Reviews. 113. 157-168 (2020)

鈥淐omorbid HIV infection and alcohol use disorders: converging mechanisms underlying neurocognitive dysfunction鈥�
Giacometti LL & Barker JM
Brain Research. 1723. Special issue on: Neurocognitive Impairment in People Living with HIV (2019)

"Sex differences in ethanol reward seeking under conflict in mice"
Xie, Q, Buck, LA, Bryant, KG & Barker, JM
Alcoholism: Clinical and Experimental Research. 43(7): 1556-1566 (2019)

鈥淚nactivation of ventral hippocampus projections prevents the expression of contingency insensitive reward seeking鈥�
Barker JM, Bryant KG & Chandler LJ
Learning and Memory. 26(1): 1-8 (2019)

鈥淪ex differences in incentive motivation and the relationship to the development and maintenance of alcohol use disorders鈥�
Barker, JM & Taylor, JR
Physiology and Behavior. 203:91-99 (2019)

鈥淗abitual behavior is mediated by a shift in response-outcome encoding in infralimbic cortex鈥�
Barker, JM, Glen, WB, Linsenbardt, DN, Lapish, CC & Chandler, LJ
eNeuro. 4(6) (2018)