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Biochemistry of Health and Disease (BHAD) Students & Alumni

Student & Alumni News

Elizabeth D鈥橪auro Receives 2024 Dean鈥檚 Travel Award

Congratulations to Elizabeth D鈥橪auro, recipient of the Dean鈥檚 Travel Award for the spring 2024 award cycle. D鈥橪auro is a PhD candidate in the Biochemistry of Health and Disease program. The Dean鈥檚 Travel Award is meant to partially defray the cost of attending a scientific meeting at which a graduate student is making a presentation, that is related to the student鈥檚 graduate study. In this cycle, each award was offered at the maximum of $750.00 per awardee.

Dr. Lauren Bailey, Drexel biochemistry graduate program alumnus.

Unlocking the Secrets of HIV

Research by recent graduate Dr. Lauren Bailey is helping to advance our understanding of the structure of HIV and how an inhibitor may cause the inactivation of the virus.

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Honors and Distinctions

Giang Le Minh (mentor: Mauricio Reginato, PhD) won the Bondi Fellowship 2024.

Photis Rotsides (mentor: Patrick Loll, PhD) won the Jane Clifford Best PHD Thesis Award 2024.

Ana Dumetriscu (mentor: Shae Padrick) won the Jane Clifford Best MS Thesis Award 2024.

Photis Rotsides, PhD candidate in the Biochemistry of Health and Disease program, gave an invited talk titled 鈥淓lucidating the antibiotic sensing mechanism of VanB vancomycin-resistant Enterococci鈥 at Experimental Biology 2022, the annual meeting of the American Society for Biochemistry and Molecular Biology.

Photis Rotsides (mentor: Patrick Loll, PhD) was awarded 3rd Place Outstanding Senior Graduate Student Poster at Discovery Day 2021.

Lina Maciunas, a Biochemistry graduate student, was one of five platform presenters to be highlighted in a news article about the College of Medicine's annual day of research, Discovery Day. Read the article.

Megan Meuser won the Bondi Fellowship 2020.

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Fellowships

Giang Le Minh (mentor: Mauricio Reginato, PhD) won the Dean鈥檚 Fellowship 2022.

Megan Meuser won the Bondi Fellowship 2020.

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Recent Dissertation Defense

Photis Rotsides, PhD (2024)
Mentor: Patrick Loll, PhD
Doctoral Dissertation: The Antibiotic Sensing Mechanism of VanS from Type-B Vancomycin-Resistant Enterococci

Giang Le Minh, PhD (2023)
Mentor: Mauricio Reginato, PhD
Doctoral Dissertation: Understanding mechanisms of OGT/O-GlcNAc regulation of breast cancer stem cells

Meagan Tomasso, PhD (2023)
Mentor: Shae Padrick, PhD
Doctoral Dissertation: Cdc42EP3-bound septin filaments promote actin filament assembly

Megan Meuser, PhD (2021)
Doctoral Dissertation: Pharmacological and biological inhibition of HIV-1 entry

Kristie D. Cox, PhD (2020)
Mentor: Marilyn Jorns, PhD
Doctoral Dissertation: Investigating SQOR-catalyzed H2S Metabolism and its Therapeutic Potential in Heart Failure

Lina Maciunas, PhD (2020)
Mentor: Patrick Loll, PhD
Doctoral Dissertation: Activation of VanR/VanS, the Two-Component System that Regulates Vancomycin Resistance

Jennifer Koch, PhD (2020)
Mentor: Patrick Osei-Owusu, PhD
Doctoral Dissertation: Influence of Physiologic and Environmental Factors on the Role of Regulator of G Protein Signaling 2 (RGS2) in Vascular Remodeling During Pregnancy

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Recent MS Thesis Defense

Ana Dumitrescu, MS (2024)
Mentor: Shae Padrick, PhD
Thesis: Development of novel fungal Arp2/3 complex inhibitors

Eric Brinckman, MS (2023)
Mentor: Shae Padrick, PhD
Thesis: Septin Filament Assembly Conditions and Fluorescent Assay Development

Ryan Sharp, MS (2022)
Advisor: Mauricio Reginato, PhD
Thesis: Regulation of NuRD complex proteins by O-GlcNAc transferase in breast cancer cells

Bridget Ryan, MS (2022)
Advisor: Karen Berkowitz, MD
Thesis: The role of CHTF18 in male meiotic cohesion

Thuraya Saleh H Alruiwaili, MS (2021)
Advisor: Srinivas Somarowthu, PhD
Review (non-thesis MS): Long non-coding RNAs in aging

Prajakta Dilipkumar Mehetre, MS (2020)
Advisor: Shae Padrick, PhD
Thesis: Identification of the BORG2 Actin Binding Element

Eric Rossi, MS (2020)
Thesis: Structure, Function and Interactions of the HIV-1 capsid protein

Rebecca A. Rhodes, MS (2020)
Advisor: Shae Padrick, PhD
Thesis: SEPT9 Binds Actin Through a Novel Binding Motif

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Graduate Placements

Megan Meuser, PhD '21, is a postdoctoral associate at Yale University.

Kristie D. Cox, PhD '20, is a postdoctoral associate at Medical University of South Carolina. Kristie did her thesis research work under the guidance of Dr. Marilyn Jorns.

Lina Maciunas, PhD '20, is a bench scientist l3 at Glaxo Smith Kline. Lina did her thesis research work under the guidance of Dr. Patrick Loll.

Prajakta Mehetre, MS '20, is a research associate II at Broad Institute of MIT and Harvard. Prajakta did her thesis research work under the guidance of Dr. Shae Padrick.

Rebecca Rhodes, MS '20, is a protein scientist at the Janssen Pharmaceutical Companies. Rebecca did her thesis research work under the guidance of Dr. Shae Padrick.

Courtney Fesko, MS '18, is a characterization scientist at Eurofins Lancaster Laboratories. Courtney did her thesis research work under the guidance of Dr. Joris Beld.

Kristie Cox, PhD '20, is a postdoctoral scholar at Medical University of South Carolina. Kristie did her dissertation work under the guidance of Dr. Marilyn Jorns.

Jennifer Koch, PhD '20, is a postdoctoral fellow at Temple University. Jennifer did her dissertation work under the guidance of Dr. Patrick Osei-Owusu.

Neha Manjari Akella, PhD '19, is a postdoctoral fellow at BC Children’s Hospital Research Institute. Neha did her dissertation work under the guidance of Dr. Mauricio Reginato.

Nadish Goyal, PhD '17 is a postdoctoral researcher at 91制片厂.

Peining Jimmy Xu, PhD '17, is a postdoctoral researcher at 91制片厂.

Elizabeth Upton, PhD, has accepted the position of assistant medical director at MedEdNow, a health care communications company in New York City. Elizabeth did her dissertation work under the guidance of Dr. Pat Loll.

Kate Beishline, PhD, has accepted the position of assistant professor of biology at Bloomsburg University of Pennsylvania. Kate did her dissertation work under the guidance of Dr. Jane Azizkhan-Clifford.

Scott Melideo, PhD '15, is an instructor of chemistry at Bucks County Community College.

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Selected Publications

Kriti Acharya


Acharya K, Rashad AA, Moraca F, Klasse PJ, Moore JP, Abrams C, Chaiken I
Proteins. 2017 May;85(5):843-851

Neha M. Akella

"O-GlcNAc Transferase Regulates Cancer Stem-like Potential of Breast Cancer Cells"
Akella NM, Le Minh G, Ciraku L, Mukherjee A, Bacigalupa ZA, Mukhopadhyay D, Sodi VL, Reginato MJ
Molecular Cancer Research. 18(4):585-598 (2020)


Akella NM, Le Minh G, Ciraku L, Mukherjee A, Bacigalupa ZA, Mukhopadhyay D, Sodi VL, Reginato MJ
Mol Cancer Res. 2020 Apr;18(4)


Akella NM, Ciraku L & Reginato MJ
BMC Biol. 2019, July 4;17(1):52. doi: 10.1186/s12915-019-0671-3

Emilia Arturo

"Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium"
Arturo EC, Gupta K, Hansen MR, Borne E, Jaffe EK
J Biol Chem 294, 10131-10145 (2019)


Arturo EC, Gupta K, Hansen MR, Borne E & Jaffe EK
J Biol Chem. 2019, June 28;294, 10131-10145.


Arturo EC, Gupta K, Héroux A, Stith L, Cross PJ, Parker EJ, Loll PJ, Jaffe EK
Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2394-9. doi: 10.1073/pnas.1516967113. Epub 2016 Feb 16

Kristie Augustin


Augustyn KD, Jackson MR, Jorns MS
Biochemistry. 2017 Feb 21;56(7):986-996

Lauren Bailey


Bailey LD, Kalyana Sundaram RV, Li H, Duffy C, Aneja R, Rosemary Bastian A, Holmes AP, Kamanna K, Rashad AA, Chaiken I
ACS Chem Biol. 2015 Dec 18;10(12):2861-73

Kate Beishline


Beishline K, Azizkhan-Clifford J
FEBS J. 2015 Jan;282(2):224-58


Beishline K, Azizkhan-Clifford J
Methods Mol Biol. 2014;1170:41-59


Beishline K, Kelly CM, Olofsson BA, Koduri S, Emrich J, Greenberg RA, Azizkhan-Clifford J
Mol Cell Biol. 2012 Sep;32(18):3790-9

Julianna Deakyne


Deakyne JS, Huang F, Negri J, Tolliday N, Cocklin S, Mazin AV
J Biol Chem. 2013 Nov 1;288(44):31567-80

Hollie Flick


Flick HE, Lalonde JM, Malachowski WP, Muller AJ
Int J Tryptophan Res. 2013 Aug 19;6:35-45

Rama Karadsheh


Karadsheh R, Meuser ME, Cocklin S
Molecules. 2020 Mar 21;25(6):1430

Sergey Karakashev


Karakashev SV, Reginato MJ
Cancer Manag Res. 2015 Aug 12;7:253-64


Karakashev SV, Reginato MJ
Oncotarget. 2015 Feb 10;6(4):1967-80

Mollie Kelly


Kelly ML, Astsaturov A, Rhodes J, Chernoff J
Dev Cell. 2014 May 12;29(3):350-9


Kelly ML, Astsaturov A, Chernoff J
Cell Mol Life Sci. 2013 Nov;70(22):4223-8


Kelly ML, Chernoff J
Cell Logist. 2012 Apr 1;2(2):84-88


Kelly ML, Chernoff J
Mol Cell Biol. 2011 Feb;31(3):386-7

Jennifer Koch


Koch JN, Dahlen SA, Owens EA, Osei-Owusu P.
J Am Heart Assoc. 2019 May 7;8(9):e010917

Giang Le Minh

鈥淥n a sugar high: Role of O-GlcNAcylation in cancer鈥
Le Minh G, Esquea EM, Young RG, Huang J, Reginato MJ
J Biol Chem. 2023

鈥淜ruppel-like factor 8 regulates triple negative breast cancer stem cell-like activity鈥
Le Minh G, Esquea EM, Dhameliya TT, Merzy J, Lee MH, Ball LE, Reginato MJ
Front Oncol. 2023

鈥淩ole of O-GlcNAcylation on cancer stem cells: Connecting nutrient sensing to cell plasticity鈥
Le Minh G, Reginato MJ
Adv Cancer Res. 2023

Scott Melideo


Melideo SL, Jackson MR, Jorns MS
Biochemistry. 2014 Jul 22;53(28):4739-53

Megan Meuser

"Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow"
Meuser ME, Reddy PAN, Dick A, Maurancy JM, Salvino JM, Cocklin S
J Med Chem. 64(7):3747-3766 (April 8, 2021)


Meuser ME, Rashad AA, Ozorowski G, Dick A, Ward AB, Cocklin S.
Molecules. 2019 Apr 22;24(8). pii: E1581. doi: 10.3390/molecules24081581.


Meuser ME, Murphy MB, Rashad AA, Cocklin S
Molecules 2018 Aug 3;23(8)

Caroline Rajiv


Rajiv C, Jackson SR, Cocklin S, Eisenmesser EZ, Davis TL
Biochem J. 2017 Oct 25;474(21):3689-3704

Photis Rotsides

鈥淒iazirine Photoprobes for the Identification of Vancomycin-Binding Proteins鈥
Rotsides P, Lee PJ, Webber N, Grasty KC, Beld J, Loll PJ
ACS Bio Med Chem Au. 2023

Geetika Sethi


Sethi G, Pathak HB, Zhang H, Zhou Y, Einarson MB, Vathipadiekal V, Gunewardena S, Birrer MJ, Godwin AK
PLoS One. 2012;7(10):e47086

Yuliya Skorobogatoko


Skorobogatko Y, Landicho A, Chalkley RJ, Kossenkov AV, Gallo G, Vosseller K
J Biol Chem. 2014 Feb 7;289(6):3602-12

Meagan Tomasso

鈥淏ORG family proteins in physiology and human disease鈥
Tomasso MR, Padrick SB
Cytoskeleton (Hoboken). 2023

Elizabeth C. Upton


Upton EC, Maciunas LJ, Loll PJ
PLoS One. 2019 Jan 24;14(1):e0210627

Jimmy P. Xu


Xu JP, Branson JD, Lawrence R, Cocklin S
Bioorg Med Chem Lett. 2016 Feb 1;26(3):824-828. doi: 10.1016/j.bmcl.2015.12.087. Epub 2015 Dec 25


Contact Information

 

Biochemistry of Health and Disease Program
Division of Biomedical Science Programs
Graduate School of Biomedical Sciences and Professional Studies
2900 W. Queen Lane, Suite G24
Philadelphia, PA 19129
 
245 N. 15th Street
New College Building
Philadelphia, PA 19102

Amanda Mangano
Academic Coordinator
   267.359.2322
   215.843.5810 (Fax)
  amm523@drexel.edu
  biograd@drexelmed.edu

 

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