91制片厂

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Zoe Zhang

Fengqing Zoe Zhang, PhD

Associate Professor of Psychology
Department of Psychological and Brain Sciences
Office: Stratton 316
fengqing.zhang@drexel.edu
Phone: 215.553.7172

Additional Sites:



Education:

PhD, Statistics, Northwestern University, 2014.

Curriculum Vitae:

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Research Interests:

  • Brain development and aging
  • Clinical trials
  • Design of experiments
  • Machine learning
  • Mental health and neuropsychiatric disorders
  • Multimodal neuroimaging
  • Wearable computing and mHealth

Bio:

Fengqing (Zoe) Zhang, PhD, is an associate professor in the Department of Psychological and Brain Sciences. Prior to joining 91制片厂, she obtained her PhD degree in Statistics at Northwestern University. Her research interests primarily center on the development of multimodal integrative approaches and advanced statistical methods to improve our understanding of health and aging. Specifically, her lab focuses on modeling complex, high-dimensional data, such as neuroimaging (e.g., MRI, DTI, fMRI, PET) and rich behavioral datasets, to investigate brain development and aging, neurodegenerative diseases (e.g., Alzheimer鈥檚 disease), and psychiatric disorders. Her methodological approaches include machine learning, Bayesian inference, and high dimensional data analysis. She also specializes in the design and statistical analysis of clinical trials, particularly focusing on sample size optimization, adaptive designs, and enrichment strategies. In addition, she works on statistical methods development to inform real-time, individualized treatment sequences (e.g., Just-in-Time Adaptive Interventions) and to integrate multimodal data from wearable devices (e.g., fitness trackers, heart rate monitors).

Impact:

Zhang鈥檚 work in quantitative modeling is driven by the goal of enhancing our understanding of complex and high-dimensional data and, ultimately our ability to fully utilize the informational complexity for new levels of scientific discovery. As we enter the era of Big Data, characterized by the rapid growth of data generation, there is immense potential to gain new insights into human behavior, health, and aging. Though promises are held, the increasing amount of data, the different types of data from heterogeneous sources, and required fast speed of data processing pose great challenges to data management and analysis. Zhang and her team are committed to making a difference in the statistical thinking and computational approaches required to handle these challenges.

Selected Publications:

  • Ferariu, A., Chang, H., Taylor, A., & Zhang, F. (2024). Alcohol Sipping Patterns, Personality, and Psychopathology in Children: Moderating Effects of Dorsal Anterior Cingulate Cortex (dACC) Activation. Alcohol: Clinical and Experimental Research. 48(8), 1492-1506.
  • Zhang, F., Chang, H., Schaefer, S. M., & Gou, J. (2023). Biological Age and Brain Age in Midlife: Relationship to Multimorbidity and Mental Health. Neurobiology of Aging, 132, 145-153.
  • Zhang, F., Gou, J. (2023). Sample Size Optimization for Clinical Trials Using Graphical Approaches for Multiplicity Adjustment. Statistics in Medicine, 42(28), 5229-5246.
  • Kim, B., Niu, X., and Zhang, F. (2023), Functional Connectivity Strength and Topology Differences in Social Phobia Adolescents with and without ADHD Comorbidity. Neuropsychologia, 178, 108418.
  • Zhang, F., and Gou, J. (2022), A Unified Framework for Estimation in Lognormal Models. Journal of Business & Economic Statistics, 40(4), 1583-1595.
  • Niu, X., Gou, J., Chang, H., Lowe, M., and Zhang, F. (2022), Classification model with weighted regularization to improve the reproducibility of neuroimaging signature selection. Statistics in Medicine 41(25), 5046-5060.
  • Taylor, A., Zhang, F., Niu, X., Heywood, A., Stocks, J., Feng, G., Popuri, K., Beg, M.F., Wang, L.; Alzheimer's Disease Neuroimaging Initiative (2022), Investigating the temporal pattern of neuroimaging-based brain age estimation as a biomarker for Alzheimer's Disease related neurodegeneration. Neuroimage 263, 119621.
  • Zhang, F., and Gou, J. (2022), Machine learning assessment of risk factors for depression in later adulthood. The Lancet Regional Health–Europe, 18.
  • Landrigan, J., Zhang, F., and Mirman, D. (2021), A Data-Driven Approach to Post-Stroke Aphasia Classification and Lesion-Based Prediction. Brain 144(5), 1372-1383.
  • Zhang, F., and Gou, J. (2021), Refined Critical Boundary with Enhanced Statistical Power for Non-Directional Two-Sided Tests in Group Sequential Designs with Multiple Endpoints. Statistical Papers, 62(3), 1265-1290.
  • Niu, X., Zhang, F., Kounios, J., and Liang, H. (2020), Improved Prediction of Brain Age Using Multimodal Neuroimaging Data. Human Brain Mapping 41(6), 1626-1643.
  • Zhang, F., and Gou, J. (2019), Control of False Positive Rates in Clusterwise fMRI Inferences. Journal of Applied Statistics 46(11), 1956-1972.
  • Zhang, F., Wang, J.-P., Jiang, W. (2019). An Integrative Classification Model for Multiple Sclerosis Lesion Detection in Multimodal MRI. Statistics and Its Interface 12(2), 193-202.
  • Zhang, F., Tapera, T.M., and Gou, J. (2018), Application of a New Dietary Pattern Analysis Method in Nutritional Epidemiology. BMC Medical Research Methodology 18, 119.
  • Zhang, F., Jiang, W., Wong, P.C.M., and Wang, J.-P. (2016), Bayesian Probit Model with Spatially Varying Coefficients and Its Application to Functional Magnetic Resonance Imaging. Statistics in Medicine 35(24), 4380-4397.https://onlinelibrary.wiley.com/doi/abs/10.1002/sim.6999